For genotyping as part of the Bipolar Genome Study (BiGS), a total of 1,566 unrelated BDI subjects of European Ancestry were selected from those collected as part of Wave 5 by the NIMH Genetics Initiative for Bipolar Disorder at 11 sites across the United States. All subjects provided written informed consent according to the local Internal Review Boards (IRBs) and were interviewed using the Diagnostic Interview for Genetic Studies (DIGS; 31). Information was also obtained from family informants and medical records and reviewed along with the interview by a panel of experienced clinicians to obtain a final best-estimate diagnosis.
