Chunk #21 — Effects of DYN/KOR Activity on Ethanol-Conditioned Behavior and Consumption — Operant Ethanol Self-Administration and Relapse-Like Behavior
on drinking compared to non-dependent subjects. Non-dependent P-rats were also shown to be sensitive to the effects of nor-BNI on ethanol self-administration responding under fixed and progressive ratio schedules, spontaneous recovery, and relapse (Cashman and Azar, 2014; Rorick-Kehn et al., 2014; Deehan et al., 2012). To our knowledge, differences in DYN tone and/or KOR expression in P-rats compared to NP-rats or their progenitor strain (Wistar rats) have not been characterized, but may potentially contribute to differences in sensitivity of these rats to KOR antagonism.
