Chunk #0 — Methods Summary — Biological materials and sequencing libraries

Source

Charting a dynamic DNA methylation landscape of the human genome.

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Genomic DNA was fragmented to 100–500 bp using a Covaris S2 sonicator. DNA fragments were cleaned-up, end-repaired, A-tailed, and ligated with methylated paired-end adapters (purchased from ATDBio). See Supplementary Information for details.