Our results provide evidence that CSA-associated risk for alcohol-related outcomes is moderated by the H2 haplotype. We first confirmed that a history of CSA is associated with significant risk for alcohol consumption and lifetime DSM-IV alcohol dependence in our sample; the H2 haplotype was not associated with risk for either of these outcomes. We found that, for both alcohol consumption and dependence, a G × E interaction involving CSA and the H2 haplotype is associated with significant protective effects. In those with the H2 haplotype, we observed no significant CSA-associated risk for either higher alcohol consumption or alcohol dependence.
