Several other tools to support rare variant meta-analysis are now available (Lee et al., 2013; Lumley et al., 2012; Tang and Lin, 2013; Voorman et al., 2013). We have tried to complement these tools by adding support for modeling of related individuals and the X chromosome, additional QC statistics, directly using compressed files to facilitate sharing and implementing conditional analyses to disentangle the contributions of nearby variants, common or rare.
