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Chunk #10 — METHODS — Genotyping and Data Cleaning

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Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.
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All genotyping was performed by the Center for Inherited Disease Research (CIDR). The COGA and FSCD samples were genotyped using Illumina Human1Mv1_C BeadChips. COGEND subjects were genotyped using two genome-wide SNP arrays: Illumina Human1Mv1_C and Illumina HumanOmni2.5M. Extensive cleaning was undertaken to ensure high-quality genotyping by examining batch effects, call rates, and other quality metrics (11).