Chunk #20 — MATERIALS AND METHODS — Simulation of BK channel currents in response to Ca2+ sparks

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Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes.

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of release from the spark, τ and Po,ss will change. If Po(t) < Po,ss, an activation τ based on the opening rate of BK channels is used; otherwise, a deactivation τ based on the closing rate is used (see Figs. 7 and 8). The simulation does not contain any explicit spatial component; distance from a spark to a BK cluster is incorporated by the choice of [Ca(t)] to which each cluster is exposed.