testing. We tested whether any observed associations were present in substance naïve children of African ancestry (n=997), with polygenic risk scores generated using summary statistics generated from individuals of African ancestry (n= 62,447). Finally, we expected that variability in brain structure may indirectly link alcohol involvement PRS to behavioral risk factors (i.e., cognition and externalizing problems) believed to play an etiologic role in the development of substance use disorder according to stage-based theories of addiction (13).
