MOAFTS is a longitudinal investigation of alcohol-related problems and associated psychopathology in female adolescents and young adults. Twins born to Missouri-resident parents between July 1, 1975 and June 30, 1985 were identified through birth records and recruited from 1995 to 1999. Cohorts of 13-, 15-, 17-, and 19-year-old twin pairs and their families were ascertained in the first two years, with new cohorts of 13-year-old twins and their families added in the subsequent two years. Parental diagnostic interviews were collected at baseline in 78% of the families recruited and eligible for participation. Baseline (Wave 1) interviews were completed with 3,258 twins. Wave 3 retest interviews were conducted with a subset of Wave 1 participants (n = 1,370) two years after Wave 1 assessments. (Data were not drawn from Wave 2 interviews, as they did not cover all domains of interest.) Wave 4 assessments were conducted from 2002 to 2005 with 3,787 twins (80% of twins identified from birth records) and contained detailed trauma history assessment. Wave 5 interviews were conducted between 2005 and 2008 with 3,428 twins. Data from Waves