Bivariate linkage disequilibrium (LD) score regression (LDSC) 35, 36 analyses were run on the sex-specific meta-analyzed summary statistics. The primary analyses (with greatest power) are those for the full PGC + iPSYCH sample; we also examined estimates in the PGC and iPSYCH samples separately using LDSC and a second method, genomic relatedness matrix restricted maximum likelihood (GREML), using genome-wide complex trait analysis (37). Because of strict restrictions on access to individual genotypes, bivariate GREML analyses (38) were performed separately in PGC and iPSYCH. Analyses were restricted to European-only samples. Sex-specific heritability was estimated using univariate models (see Supplement for detailed methods).
