Chunk #40 — 4. Selectively bred high alcohol-consuming rat lines and their phenotypic characteristics — 4.5. University of Chile B and University of Chile A rats
in alcohol dehydrogenase (ADH) and/or ALDH can play a protective or permissive role in the development of alcohol abuse and dependence by increasing or decreasing blood acetaldehyde levels, respectively (Eriksson, 2001; Quintanilla et al., 2006). In summary, while research with the other selectively bred high alcohol-consuming rat lines has focused more on CNS neurobiology, research with the UChB and UChA lines has provided important information on genetic differences in alcohol and/or acetaldehyde metabolism and their role in the development of alcohol abuse and dependence.
