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Chunk #28 — TRANSLATIONAL IMPLICATIONS

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Twin studies and their implications for molecular genetic studies: endophenotypes integrate quantitative and molecular genetics in ADHD research.
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and ADHD behaviors. This is particularly valuable where twin studies establish that the same behaviors in different settings (e.g., across tasks or situations) do not share the same environmental factors. The validation of increased ADHD correlates in unaffected relatives of probands suggests that ADHD behaviors, throughout the lifespan, are associated with disruptions in interpersonal relationships, mood instability, employment problems, and chaotic living arrangements.75 If relatives of ADHD probands share these characteristics, the stress-diathesis hypothesis would suggest that this would create a disruptive environment for the individual with high ADHD liability, which in turn would give clinicians an important area for targeting intervention or symptom management.