SERINC2 encodes serine incorporator 2 (Serinc2) that belongs to a cell membrane carrier protein family of Serinc1–5. High concentration of Serinc2 is seen in neurons of the hippocampus and cerebral cortex (Grossman et al., 2000). Serinc2 co-localizes with lipid biosynthetic enzymes (i.e., serine palmitoyltransferase) in endoplasmic reticulum membranes and interacts with an intracellular serine-synthesizing protein complex that included 3-phosphoglycerate dehydrogenase (Nedivi et al., 1993). It serves as an effector molecule that incorporates serine into membranes and facilitates the synthesis of two serine-derived membrane lipids, phosphatidylserine and sphingolipids (long-chain amino alcohols; Inuzuka et al., 2005). Phosphatidylserine is a phospholipid component of cell membranes, with the highest concentrations in the brain. At least 25 intervention studies suggested that consumption of phosphatidylserine supplement may reduce the risk of dementia and cognitive dysfunction in the elderly (Schreiber et al., 2000; Jorissen et al., 2001). Phosphatidylserine supplement has been approved by the U.S. Food and Drug Administration to treat memory deficit disorders such as Alzheimer’s disease and other forms of dementia, to support healthy cognitive function during aging, and to remediate cognitive deficits as a
