We repeated these analyses including, rather than excluding, participants with a history of a transient ischemic attack or stroke (Table 1). The results were similar although the associations were slightly weaker, in general (data not shown). We also examined associations with previously reported candidate SNPs, or their proxies, none of which was significant after correction for multiple testing (Appendix, Section 9). In addition, we examined associations with top SNPs in the Ninjurin-2 gene associated with ischemic stroke in a recent CHARGE GWAS meta-analysis7 and found none significantly associated with MRI-infarcts. Finally, we explored relations between ischemic stroke and the 23 SNPs in MACROD2 (Table 2) in the recent CHARGE GWAS meta-analysis on ischemic stroke.7 No significant association of these SNPs with ischemic stroke was identified.
