After imputation using the 1000 Genomes reference panel excluding SNPs with MAF <3% in both AAs and EAs, 10 421 983 SNPs common to both discovery data sets (9,519,112 in AAs, 6,331,841 in EAs) were included in association analyses. There was little evidence for inflation of P-values in AAs but some in EAs (Supplementary Figure S1).