One hundred pedigrees containing 885 individuals were used in the genetic analyses. Of these, 528 individuals were from 41 extended families where multiple family members were directly interviewed, data from these individuals were used to calculate heritability of the phenotypes. Fifty-nine families have only a single individual with direct interview data. The individuals in these 59 families were not included in the linkage analyses but were included in the comorbidity analyses and in the calculation of trait means and variance in order to determine the impact of covariates. Two hundred and fifty-one individuals from the 41 extended pedigree families have both genotype and phenotype data and were used in the linkage analyses. The family sizes for the 41 families ranged between 4 and 38 members (average 13.5±10) with between 2 and 15 individuals having both genotype and phenotype data (average 5.4±4.2). The 251 individuals within the 41 families that were genetically informative include: 77 parent-child, 212 sibling, 26 half sibling, 8 grandparent-grandchild, 151 avuncular, and 245 cousin relative pairs. Only sib, half-sib, avuncular and cousin pairs were included as being
