and those for obesity-related metabolic dysregulations with atypical MDD. We tested our hypothesis in a sample of 3,230 Dutch adults with established psychiatric diagnoses and GWAS data. We examined for MDD and its subtypes: 1) the genetic overlap with major psychiatric disorders (MDD, bipolar-disorder, schizophrenia) and metabolic traits (BMI, C-reactive protein and triglycerides, capturing central metabolic dysregulations found to be strongly linked with atypical MDD(11;18;19)) using genomic profile risk scores (GPRS); 2) the proportion of variance in liability explained by the joint effect of all common SNPs using genomic-relationship-matrix restricted maximum likelihood (GREML) methods. MDD subtypes were identified by using both data-driven techniques and a parsimonious sub-phenotyping strategy focusing on appetite and weight symptoms.
