Chunk #4 — INTRODUCTION

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Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.

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including outcomes other than depression.22 One key issue contributing to disputes over the appropriateness of the prior reports and meta-analyses is the heterogeneity of the studies.22 Heterogeneity pervades many key factors in the prior analyses, including measurements of depression and stress, genetic ancestry, and statistical models.