In rat models of WE induced using pyrithiamine, the dominant MRS pattern is a reduction in both NAA and Cho in several brain regions (Lee et al. 1995, 2001; Rose et al. 1993), including the thalamus (Navarro et al. 2008, 2005; Pfefferbaum et al. 2007). Researchers also frequently report elevations in lactate (Navarro et al. 2005, 2008). Precipitation of WE with glucose (resulting in seizures) is associated with further decreases in NAA and Cho and, significantly, an elevation in lactate (Zahr et al. 2014a). Treatment with thiamine is associated with recovery in Cho levels (Lee et al. 1995).
