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Chunk #11 — Effects of BMI variants on other traits

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Genetic studies of body mass index yield new insights for obesity biology.
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= 0.0019) were in high LD (r2 > 0.7) with one or more GWS SNPs in the National Human Genome Research Institute (NHGRI) GWAS catalogue (P < 5 × 10−8), even after removing anthropometric trait-associated SNPs. These SNPs were associated not only with cardiometabolic traits, but also with schizophrenia, smoking behaviour, irritable bowel syndrome, and Alzheimer’s disease (Supplementary Table 17a, b).