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Chunk #19 — RESULTS — ASSOCIATION ANALYSES OF SLC1A1 AND OCD

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A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.
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We then genotyped the 3 eQTL SNPs we described and 3 additional SNPs within SLC1A1 that have been individually associated with OCD in prior family-based studies16,17 in our collection of 325 probands and 662 controls matched for ethnicity and sex. Table 1 details genomic location and linkage disequilibrium of the 6 analyzed markers. As presented in Table 1, none of these 6 SNPs were individually associated with OCD after permutation-based multiple-testing correction. We also performed these analyses separately for males and females and did not observe significant results (data not shown).