To identify the set of uncorrelated PGSs, 10 permuted trans-eQTL Z-score matrices from the combined trans-eQTL analysis were first confined to the pruned set of SNPs. Those matrices were then used to identify 3,042 uncorrelated genes based on Z-score correlations (absolute Pearson R<0.05). Next, permuted eQTS Z-score matrices were confined to uncorrelated genes and used to calculate pairwise correlations between all genetic risk scores to define a set of 1,873 uncorrelated PGSs (Pearson R2<0.1).
