compared with 26% in the intermediate group and none in the low group. The progression of AUD symptoms and binge-drinking frequency are shown in Figure 1A and B. Alcohol responses, relative to placebo, for stimulation, sedation, like, and want more for the AUD groups are shown in Figure 1C and F. There was a linear progression in responses with the high AUD symptom group showing pronounced stimulation, like, and want more ratings compared with the other groups. Sedation did not differ across groups.