While this review focuses on pharmacogenetic studies of treatment for AUD in four different ancestries including European, East Asian, African American, and American Indian/Alaskan Native, it is important to acknowledge that there is much variation in regards to genetics, culture and environmental exposure within each broader classification.69 Another limitation of many pharmacogenetic studies is that participants are often asked to self-identify as a specific ethnicity. Due to recent genetic admixture, it is becoming increasingly difficult to rely on self-reports for pharmacogenetic studies. Therefore, the use of ancestry-informative markers is encouraged to accurately detect stratification in the aforementioned admixed populations such as Latinos and Hispanics.
