Results from the replication analysis are shown in Table 3, with SNPs shown from genomic regions that demonstrated association (p < 0.03) in the family-based replication sample. The analysis of the case-control replication cohort did not detect significance below the multiple-testing threshold (p < 0.001) among the 85 SNPs genotyped, although three of the SNPs in the C15ORF53 region demonstrated some evidence of association in the case-control cohort (p = 0.03-0.04) as well as in the family sample (p = 0.008-0.015). The preponderance of the association evidence from the family based analysis reported in Table 3 is derived from transmission of SNP alleles to affected individuals. These transmissions are effectively independent of the population association (21). The meta-analysis (Table 3) gave p-values of 0.004-0.01 for SNPs in this region, and reinforced the association evidence for SNP rs13358880 on chromosome 5.
