Signs of hypoxia are present, as evidenced by the increases in Angiopoietin-like 4, EPAS1 (endothelial PAS domain protein 1, also known as HIF2α), HIF3α, and HIF1α (15% increase, FDR 0.26) shown in Supplemental Table S2. Analysis of upstream regulators (Supplemental Table S3) reinforces this, since the pattern of expression of the genes regulated by EPAS1 and HIF1α also indicates that they are activated.
