In 2009, the PGC published three foundational papers regarding genome-wide association studies (GWAS) (9–11). GWAS is a genomic study design that focuses on the impact of common genetic variation in almost all genes in the human genome. The initial PGC papers covered the core concepts, history, the rationale, genomic assays, statistical analysis, interpretative framework, and the importance of cross-disorder studies in psychiatry. Full background of the terminology, core concepts, and strategy of GWAS can be found in these papers. Basic terms are defined in Table S1, and a paper that serves as a “primer” can be found here. (12)
