most significant in cases fulfilling the Research Diagnostic Criteria for schizo-affective disorder. Cases fulfilling the Research Diagnostic Criteria for Bipolar Disorder type II showed a similar allele frequency as did controls.61 Future studies in larger samples, for example, the Psychiatric GWAS Consortium62 are suited to further investigate the complex association between personality and BD. For MDD, the genetic association with N is now well established as studies using different methods reveal similar results. This is beneficial for molecular genetic studies as statistical power can be increased by performing bivariate association analyses of neuroticism and MDD.
