Two previous linkage studies reported evidence for linkage of traits related to alcohol dependence and chromosome 10 markers. Agrawal et al. (35) reported suggestive linkages at the 60 and 99 cM on that chromosome to a quantitative trait based on DSM-IV AD symptoms, in a mostly EA sample – quite distant from our observed linkage peak. Schuckit et al. (36) observed suggestive linkage to the trait of “level of response to alcohol” in the region of 120–140 cM on chromosome 10; this linkage signal is far more likely to have its origin at the same genetic locus, or loci, as the one we observed. Kendler et al (37) also found modest evidence for linkage of a conduct disorder and AD-related trait in the same region. Consistent with expectations based on relatively low correlations between different SD diagnoses in our sample, the major linkage peak we observed for AD does not coincide with peaks observed for cocaine (23), nicotine (25), or opioid dependence (24), in our previous studies, with one exception: we observed “suggestive” linkages for Fagerstrom Test for Nicotine Dependence
