Reduced frontal lobe (Pfefferbaum et al., 1997; Males, 2009) and white matter (Hommer et al., 2001; O’Neill et al., 2001) volumes and impaired FC (Kaplan et al., 1985; Winterer et al., 2003; Herrera-Díaz et al., 2016) have been observed in patients with AUDs. However, studies investigating FC in patients with AUDs during the resting state have obtained inconsistent findings (Kaplan et al., 1985; Michael et al., 1993; Winterer et al., 2003; Herrera-Díaz et al., 2016). For example, Herrera-Díaz et al. (2016) reported decreased alpha connectivity in the frontal-central and occipital-parietal areas in patients with AUDs relative to normal controls, whereas Winterer et al. (2003) reported increased alpha connectivity in the left temporal-parietal area in patients with AUDs compared with normal controls.
