P50 suppression has been extensively studied as an endophenotype for schizophrenia (Freedman et al., 2003). The main assumption is that the gating deficit occurring at early stages of sensory processing can give rise to more complex cognitive deficits occurring at later processing stages, such as problems with attention and perception, cognitive fragmentation, hypervigilance, etc. (Braff and Geyer, 1990; Freedman et al., 2003).
