Chunk #48 — Online Methods — Derivation of relationship between h2 and hγ2

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Leveraging population admixture to characterize the heritability of complex traits.

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To obtain an estimate of h2 we must estimate θ, FSTC, and hγ2. The parameter θ is estimated from local ancestry inference. The parameter FSTC is estimated from assumptions about the variance explained by SNPs in each genotypic class combined with external reference panels45,46.