In the COGA sub-sample used for MVP-PTSD PRS analyses, 7.4% of the population met criteria for PTSD (Supplementary Table 3). The highest prevalent substance dependence diagnosis was alcohol dependence (29.6%), followed by cannabis dependence (22.0%), cocaine dependence (10.6%), and opioid dependence (5.0%). Of the EA sub-sample, 7.4% met criteria for PTSD, 32.8% for alcohol dependence, 20.5% for cannabis dependence, 10.3% for cocaine dependence, and 5.9% for opioid dependence. In the AA sub-sample, 7.3% met criteria for PTSD, while the highest prevalent substance dependence diagnosis was cannabis dependence (25.3%), followed by alcohol dependence (22.8%), cocaine dependence (11.3%), and opioid dependence (3.2%). No significant main effects of the MVP-PTSD PRS were observed for DSM-IV diagnoses in EA or AA individuals (Supplementary Table 11). In addition, no significant interaction effects (i.e., PRS*sex or PRS*alcohol dependence) were observed (Supplementary Tables 11 and 13, respectively). Further, the addition of the problematic alcohol use PRS did not change any of these findings (Supplementary Tables 12 and 14).
