= 0.0002). A similar result was obtained for promoter haplotypes of the LDHC (lactate dehydrogenase C) gene in which six common variants defined 7 common haplotypes, five of which were successfully cloned and tested. The strongest expression correlation was observed for a SNP located 392 bp upstream of the TSS (15% MAF), and the luciferase data strongly support the functional effect of this variant (p-value = 8.7×10−9; Figure 5B).
