assumption was satisfied for scenarios 1, 2, and 3, and so causal estimates from multivariable MR‐Egger were unbiased. When the multivariable InSIDE assumption was violated (scenario 4) the estimates from multivariable MR‐Egger were biased, yet the magnitude of bias was less compared with univariable MR‐Egger as |cov(α′,βX1)|<|cov(α,βX1)|.
