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Chunk #17 — Discussion

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Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
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It was further estimated that SNP-based genetic similarity across individuals accounted for approximately 15% of the variance in neuroticism. This estimate is larger than in earlier reports using the same technique (about 6% explained)44,46. Heritability estimates from twin studies are usually larger and range between 40 and 55%.36