We next used the entire set of five CAGES samples to estimate SNP effects and predicted cognitive phenotypes in the independent NCNG (Norwegian NeuroGognitive Genetics) sample. For gf and gc, the correlations between phenotype and predictor were, respectively, 0.076 (P = 0.028, one-sided t-test) and 0.092 (P = 0.009, one-sided t-test). Individuals with a higher predicted score had, on average, a higher phenotype. Thus, SNP effects estimated in the discovery cohort are significantly predictive of cognitive phenotype outcomes in a fully independent cohort.
