significant effects on GNL3 and ITIH4 expression in prefrontal cortices, explaining the observed aberrant brain activity in schizophrenia. Recently, a study found that the genetic variants in the 3p21.1 region affect expression of NEK4, GNL3, and PBRM1 in the frontal cortices, which in turn affected dendritic spines, cognitive function, schizophrenia, and bipolar disorder (Yang et al., 2020). This provides evidence that frontal EEG alpha oscillations may indeed be a biomarker for schizophrenia (Merrin & Floyd, 1996; Nikulin et al., 2012), although the effect has not always been consistent across studies of oscillations at this frequency (Boutros et al., 2008).
