drug use disorders. It is therefore possible that some null findings for specific drug use disorders were due to insufficient power. Another concern is that self-reported height and weight were used to calculate BMI, which could lead to underestimation (Flood, Webb, Lazarus, & Pang, 2000; Kuczmarski, Kuczmarski, & Najjar, 2001). Finally, one strength of this study, the large sample, can also be viewed as a weakness. With samples this large, even fairly small effects are significant, and their clinical significance may be questionable. Some of the significant odds ratios we found are fairly modest, but in the population as a whole, even a modestly increased risk for substance use disorders can have detectable effects in terms of costs to society, such as treatment costs, associated medical costs and effects on crime.
