Previous research has identified a higher prevalence of injuries, self-reported disability, and premature mortality as well as worse mental health, worse maternal health outcomes, and more infectious disease, chronic disease, and risk behaviors, such as substance use disorder, among adults with ACEs.3,4,5 Previous cross-sectional studies have estimated a substantial ACE-associated health economic burden in adulthood in Europe and North America,6,7 the UK,8 and California.9 To our knowledge, similar economic estimates do not yet exist for other US states or for the US in total, although the ACE-related health burden among adults is extensively documented.10,11,12,13,14,15,16 This study aimed to estimate the economic burden of health conditions associated with ACEs among US adults.