Measures of smoking. Smoking measures available in the UK Biobank were self-reported and collected at initial assessment. They included: smoking status (current, former, never – field 20116), age at initiation in years (fields 3436/2867), age at cessation in years (field 2897) and number of cigarettes smoked per day (fields 3456/2887). Anyone self-reporting to smoke more than 100 cigarettes per day was contacted for confirmation. Hand-rolled cigarette smokers were told 1 g of tobacco equates to one cigarette. We calculated duration of smoking and time since cessation. UK Biobank removed individuals smoking fewer than 1 or more than 150 cigarettes a day.