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Chunk #3 — Ventral anterior cingulate cortex during social interactions

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Ventral anterior cingulate cortex and social decision-making.
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Both sgACC and pgACC are part of agranular frontal cortex, which has correspondences in monkeys and also in rats (Wise, 2008). This is in contrast to granular dorsomedial areas involved in mental state inference, which appear to have evolved more recently (Wise, 2008). PgACC lies anterior to the genu of the corpus callosum and is cytoarchitectonically and functionally dissociable from sgACC, which occupies more ventral and posterior parts of cortex (Neubert et al., 2015; Palomero-Gallagher et al., 2015; Vogt et al., 1995, 1987). As expected from parts of cortex as close together as sgACC and pgACC, these areas have a similar connectivity profile (Neubert et al., 2015). Comparatively, however, sgACC is more strongly connected to many subcortical regions like the basal forebrain and hypothalamus than the pgACC, which in turn has relatively stronger connections to dorsal parts of medial and lateral frontal cortex (Neubert et al., 2015; Öngür et al., 1998; Price and Drevets, 2009). pgACC can also be distinguished from the midcingulate cortex in terms of functional and structural connectivity (Balsters et al., 2016b).