ones for which PSMR met the Bonferroni significance threshold and had PHEIDI > 0.05. We conducted a combination of SMR and HEIDI based on GTEx project latest (version 8) multi-tissue cis-eQTL databases99 from 13 brain regions and pituitary tissue that showed significant enrichment in MAGMA/FUMA analyses (see above). We also used cell-type-specific eQTLs in dlPFC for SMR analyses107. Finally, we used a blood UK Biobank pQTLs database of 1,463 plasma proteins40 relying on a very large population (54,306) for SMR/HEIDI analysis to evaluate biomarker potential.
