Chunk #34 — Results — Modeling the consequences of miR-9 regulation of BK transcripts

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol.

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Therefore, BK tetrameric groups can be placed into four categories of alcohol sensitivity (color-coded in Figure 7A and 7B): 1) assemblies with at least one STREX, yielding alcohol resistant channels (red), 2) ALCOREX homomers – highly activated by alcohol (light green), 3) INSERTLESS homomers – low potentiation by alcohol (dark green), and 4) ALCOREX/INSERTLESS heteromers – for which the relative alcohol sensitivity is unknown (medium green).