very significant deviations than those with high frequency, and there are many SNPs in which the heterozygous class is deficient. This feature may be due to the Birdseed algorithm calling by 96-sample plate, which may make calling genotypes of SNPs with rare alleles more difficult. We should emphasize, however, that extreme deviations are rare with both platforms (<0.3% of SNPs having p-value< 10−10).
