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Chunk #12 — Results — Genetic relationship of OCD with other phenotypes

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Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.
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Suicide attempt (rG= 0.40), history of childhood maltreatment (rG= 0.37), and tiredness (rG= 0.36) were also notable for strong positive associations with OCD. Of the assessed neurological disorders, OCD was only significantly correlated with migraine (rG= 0.15). Some autoimmune disorders, such as Crohn’s disease (rG= −0.13), ulcerative colitis (rG = −0.14), and inflammatory bowel disease (rG = −0.14), showed negative correlations with OCD (see Fig. 3, Supplementary Table 18 for all genetic correlation estimates, 95% CI and P-values, Supplementary Note 6 for a more in depth discussion of all significant genetic correlations, and Supplementary Table 19 and Supplementary Figs. 41 and 42 for sub-group specific genetic-correlation estimates).