We next examined the associations between AUD and divorce. In the EA sample, we found that lifetime AUD and psychiatric comorbidities, including cannabis dependence/abuse, frequent tobacco use, and major depressive disorder, were all independently associated with higher likelihood of divorce, while also accounting for the alcohol problems polygenic score. These findings are consistent with prior evidence in population-based samples (Kessler et al., 1998; Waldron et al., 2011). Neither the alcohol problems polygenic score nor psychiatric comorbidities altered the association between AUD and divorce. This highlights the unique predictive power of AUD on divorce above and beyond the potentially confounding effects of genetic predispositions and common comorbid externalizing and internalizing disorders.
