The sequencing of the human genome provided the parts list of life, and this in turn has led to an explosion of new insights into the genetic basis of disease. Genome-wide association studies have identified risk-associated loci for major diseases, and the sequencing of human tumors has similarly identified the somatic mutations that underlie many types of cancer. The research community has benefitted from these genomic resources by being able to readily look up sequence variants in large-scale compendia of genomic variation. Such look-up tables of biology have transformed how modern research is done.
