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Chunk #13 — Discussion — 12q24

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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
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contains many additional plausable candidate genes. Other GWAS have implicated multiple variants in this region in many phenotypes (type 1 diabetes, arthritis, renal function, hemoglobin concentration/hematocrit, coronary artery disease and waist-to-hip ratio) [19]-[26] and therefore the nature of the actual causative allele and gene remains to be determined. The rs4767364 variant was also associated with UADT cancer risk in a smaller series of African Americans implying that this effect may be relevant to other populations.