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Chunk #58 — Online Methods (Limit 3,000 words, at end of manuscript, currently 2,064) — Identifying independent associations

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
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Forward stepwise conditional analysis of all significant genes was carried out using joint linear regression modeling. First, the top-ranked gene was added to the model, then the next most significant gene in a joint model is added if significant at a given p-value threshold, and so on until either all genes are added to the model, or no joint statistic reaches the significance threshold.